Temperature sensitive eIF5A mutant shows accumulation of transcripts targeted to the Nonsense Mediated Decay pathway

GSE5290

Saccharomyces cerevisiae

8 Downloadable Samples

Affymetrix Yeast Genome S98 Array (ygs98)

Submitter Supplied Information

Description

The highly conserved protein eIF5A found in archaea and all eucaryotes uniquely contains the posttranslationally formed amino acid hypusine. Despite being essential the functions of this protein and its modification remain unclear. To gain more insight into these functions temperature sensitive mutants of the human EIF5A1 were characterized in the yeast Saccharomyces cerevisiae.

PubMed ID

16987817

Publication Title

Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathway.

Total Samples

Submitter’s Institution

Max-Planck-Institut for Biochemistry

Authors

Schrader R, Young C, Kozian D, Hoffmann R, Lottspeich F

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-5290

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