Pdx1 maintains -cell identity and function by repressing an -cell program

To get a more complete picture of the transcriptional changes associated with Pdx1 loss in -cells, we conducted an mRNA microarray comparing normal islet -cells and a-cells to the reprogrammed cells from PKO mice.

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Gao T, McKenna B, Li C, Reichert M, Nguyen J, Singh T, Yang C, Pannikar A, Doliba N, Zhang T, Stoffers DA, Edlund H, Matschinsky F, Stein R, Stanger BZ