Therapy-induced PML nuclear body re-formation and p53 activation trigger acute promyelocytic leukaemia cure

The therapy-induced PML/RARA catabolism elicits the loss of APL-initiating cell self-renewal through PML NB reformation and P53 activation. These results explain the curative activity of the RA/arsenic combination, the resistance to RA of PLZF/RARA-driven APLs and they raise the prospect that activation of this PML/P53 checkpoint might have therapeutic values in other malignancies.

72

Ablain J, Rice K, Soilihi H, de Reynies A, Minucci S, de Thé H