Gene Expression in wild type and CCR5 knockout mice with lung metastasis

We have shown that C57BL/6J CCR5 knockout mice develop 30.4% 8.6% fewer B16 F10 lung nodules compared to wild type mice after the intravenous injection of 100,000 B16 F10 cells. We sought to understand this phenomenon by comparing gene expression in the lungs of these mice at 6, 24, and 48 hours after tumor injection.

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Mango RL, Wu QP, West M, McCook EC, Serody JS, van Deventer HW