Adjudin-induced germ cell loss from adult rat testes

GSE5131

Rattus norvegicus

8 Downloadable Samples

Affymetrix Rat Genome 230 2.0 Array (rat2302)

Submitter Supplied Information

Description

This is a study to explore the transcriptional changes after Adjudin treatment in adult rat testes at three time points (control, 8 hour and 4 day). Adjudin, [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide], is a potential male contraceptive that targets the Sertoli-germ cell interface and causes germ cell depletion from the seminiferous epithelium. Adjudin has been proved to be a useful model to study the mechanisms that regulate junction restructuring in the testis.

PubMed ID

17332525

Publication Title

Unraveling the molecular targets pertinent to junction restructuring events during spermatogenesis using the Adjudin-induced germ cell depletion model.

Total Samples

Submitter’s Institution

Population Council

Authors

Xia W, Mruk DD, Lee WM, Cheng CY

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-5131

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