Hippocampal transcript profile in young and middle-aged mice

We carried out a global survey of age-related changes in mRNA levels in the C57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged mice displayed a mild but specific deficit in spatial memory in the Morris water maze.

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Verbitsky M, Yonan AL, Malleret G, Kandel ER, Gilliam TC, Pavlidis P