Expression data from N/Tert-HPV E6 cells in the presence and absence of mitomycin C treatment

HPV E6 from the genus alpha 'high risk' types such as HPV16 recruit the ubiquitin ligase E6AP to ubiquitinate p53 and target it for proteasome-mediated degradation. This results in the functional inactivation of p53 in HPV16-E6 expressing cells.

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White EA, Walther J, Javanbakht H, Howley PM