Polyamides alleviate transcription inhibition associated with long GAATTC repeats in Friedreichs ataxia

GSE5040

Homo sapiens

20 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Lymphoblast cells from a patient with Freidriech's Ataxia were incubated with pyrrole-imidazole polyamides targeted to the GAA triplet repeat in the intron 1. The polyamides were shown in cell culture to increase levels of endogenous frataxin mRNA. A normal sibling derived lymphoblast cell line was used as a control.

PubMed ID

16857735

Publication Title

DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia.

Total Samples

Submitter’s Institution

The Scripps Research Institute

Authors

Burnett R, Melander C, Puckett JW, Son LS, Wells RD, Dervan PB, Gottesfeld JM

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-5040

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