Expression data from striatum of a mouse model of Huntingtons disease (HD) (HdhQ111/Q111) crossed with mGluR5 knockout mice (mGluR5-/-) and their respective controls (HdhQ20/Q20 and mGluR5+/+).

GSE50379

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

To try to investigate the mechanism behind the adaptive phenotypes observed in a mice model model of HD crossed with mGluR5 knockout, we analyzed whether mutated huntingtin (Htt) expression in a mGluR5 null background could be altering the expression of genes that might be involved in the pattern of Htt aggregation and HD-related locomotor alterations.

PubMed ID

24282028

Publication Title

Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.

Total Samples

Submitter’s Institution

Robarts Research Institute

Authors

Ribeiro FM, Devries RA, Hamilton A, Guimaraes IM, Cregan SP, Pires RG, Ferguson SS

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-50379

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