Expression data from blood and biopsies of Donor-Specific Antibody positive patients

The presence of Donor-Specific anti-HLA Antibodies (DSA) is associated with an increased risk of both acute and chronic antibody-mediated rejection (AMR) in kidney allografts. AMR has remained challenging in kidney transplantation and is the major cause of late allograft loss. However, not all patients with DSA develop AMR, leading to the question of whether this represents accommodation, if other protective mechanisms exist or if this is actually a state of pre-rejection.

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Ó Broin P, Hayde N, Bao Y, Ye B, Calder RB, de Boccardo G, Lubetzky M, Ajaimy M, Pullman J, Colovai A, Akalin E, Golden A