Genome-wide analysis of control and MMP-14 (MT1-MMP) expressing MCF-7 cells growing in three-dimensional (3D) type I collagen gels versus monolayer cell culture conditions

GSE49595

Homo sapiens

12 Downloadable Samples

Illumina HumanHT-12 V4.0 expression beadchip

Submitter Supplied Information

Description

In order to investigate the impact of MMP-14 (MT1-MMP) and three-dimensional (3D) culture conditions on the transcriptomes of a human breast adenocarcinoma cell line, we performed a microarray analysis from RNAs isolated from MCF-7 cells expressing either an empty vector (CTRL) or human MMP-14 cDNA (MT1) in monolayer (2D) and 3D collagen (3D Col) growth conditions.

PubMed ID

25774665

Publication Title

A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells.

Total Samples

Submitter’s Institution

University of Lige

Authors

Assent D, Bourgot I, Hennuy B, Geurts P, Noël A, Foidart JM, Maquoi E

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-49595

No rows found