Effects of PP2Ac over-expression on mouse nave CD4 T cell gene profile upon activation

GSE49466

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

A transgenic mouse was generated using a CD2-driven transgene containing the cDNA of Ppp2ca to achieve over-expression of PP2Ac in T cells. Nave CD4 T cells were isolated and lysed at times 0, 6, and 24 hours after stimulation with anti-CD3 and anti-CD28

PubMed ID

23918926

Publication Title

Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.

Total Samples

Submitter’s Institution

Beth Israel Deaconess Medical Center

Authors

Apostolidis SA, Rauen T, Hedrich CM, Tsokos GC, Crispín JC

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-49466

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