Genome-wide profiling of the activity-dependent hippocampal transcriptome

Activity-dependent gene expression is central for sculpting neuronal connectivity in the brain. Despite the importance for synaptic plasticity, a comprehensive analysis of the temporal changes in the transcriptomic response to neuronal activity is lacking. In a genome wide survey we identified genes that were induced at 1, 4, 8, or 24 hours following neuronal activity in the hippocampus.

24

Hermey G, Mahlke C, Gutzmann JJ, Schreiber J, Blüthgen N, Kuhl D