Gene expression in mouse hematopoietic stem and multi-potent progenitor cells with temporally defined divisional histories

Homeostatic hematopoietice stem cells (HSCs) with greater divisional history lose repopulating potential after very few cell divisions. Divisional history overrides both phenotype and immediate quiescence in determining functional activity. In GFP label retaining system GFP is progressively diluted when cells proceed through a cascade of divisions.

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Qiu J, Papatsenko D, Niu X, Schaniel C, Moore K