Expression data from tumoral thymocytes and DP thymocytes expressing an activated form of b-catenin in mouse T cells

To assess the importance of the Wnt pathway during T cell develoment, we generated a mouse line (R26-cat) in which high levels of active -catenin are maintained throughout T cell development. Young R26-cat mice (6-week-old) show a differentiation block at the CD4+CD8+ DP stage. All R26-cat mice develop T cell leukemias with a DP phenotype at 5-6 months of age.

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Kaveri D, Kastner P, Dembélé D, Nerlov C, Chan S, Kirstetter P