Designed Oligooxopiperazines as Modulators of Hypoxia-Inducible Factor Signaling

We performed gene expression profiling of oligooxopiperazines (OPs) targeting the hypoxia-inducible transcription factor complex. Treatment of cells with OPs inhibited hypoxia-inducible gene expression in A549 cells.

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Lao BB, Grishagin I, Mesallati H, Brewer TF, Olenyuk BZ, Arora PS