B cell-intrinsic STAT6 controls the germinal center response in type 2 immunity

By investigating the germinal center (GC) formation in STAT6ko/WT bone marrow-mixed chimera we found that GC formation in type 2 immune responses is dependent on B cell intrinsic expression of IL-4/IL-13-induced genes. We therefore used microarrays to find Stat6 dependent genes that are important for germinal center formation and/or organization after infection with the nematode Nippostrongylus brasiliensis (N. brasiliensis).

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Turqueti-Neves A, Otte M, Prazeres da Costa O, Höpken UE, Lipp M, Buch T, Voehringer D