Transcriptional profiling of left ventricle and peripheral blood cells in rats with post-myocardial infarction

Myocardial infarction (MI) often results in left ventricular (LV) remodeling followed by heart failure (HF). It is of great clinical importance to understand the molecular mechanisms that trigger transition from compensated LV injury to HF and to identify relevant diagnostic biomarkers. In this study, we performed transcriptional profiling of LVs in rats with a wide range of experimentally induced infarct sizes and of peripheral blood mononuclear cells (PBMCs) in animals that developed HF.

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Tulacz D, Mackiewicz U, Maczewski M, Maciejak A, Gora M, Burzynska B