PGA Human CD4+ Lymphocytes

GSE473

Homo sapiens

175 Downloadable Samples

Affymetrix Human Genome U133A Array (hgu133a), Affymetrix Human Genome U133B Array (hgu133b)

Submitter Supplied Information

Description

This project is based on the hygiene hypothesis that exposure to TB provides a protective mechanism against asthma through specific cytokines and the balance of Th1, Th2 cells. Additionally, expression changes are examined in patients with and without atopy in combination with asthma and PPD status. Expression levels were evaluated in CD4+ cells isolated from peripheral blood of 30 patients. Each patient was evaluated on the entire U133 Affymetrix GeneChip set.

PubMed ID

19216740

Publication Title

A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation.

Total Samples

175

Submitter’s Institution

Children's National Medical Center

Authors

Mobini R, Andersson BA, Erjefält J, Hahn-Zoric M, Langston MA, Perkins AD, Cardell LO, Benson M

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-473

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