Differential regulation of gene expression by two isoforms of the human transcriptional coactivator MKL1

GSE47209

Homo sapiens

9 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

We identified two isoforms of human MKL1 that differ in their N-terminal domains. Since MKL1 is a transcriptional coactivator of SRF and regulates many SRF target genes, we wanted to analyze if transcription is differentially regulated by the two isoforms upon stimulation of the Rho-actin-MKL1-SRF pathway.

PubMed ID

24424023

Publication Title

TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms.

Total Samples

Submitter’s Institution

FMI

Authors

Scharenberg MA, Pippenger BE, Sack R, Zingg D, Ferralli J, Schenk S, Martin I, Chiquet-Ehrismann R

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-47209

No rows found