Temporal Gene Expression Patterns in the skin of D6 null and wild type mice after inflammation with the chemical irritant TPA

The chemokine decoy receptor D6 internalises and degrades inflammatory CC chemokines enabling resolution of inflammation. In D6 deficient mice (D6 KO), otherwise innocuous cutaneous inflammatory stimuli induce a grossly exaggerated inflammatory response that bears many similarities to human psoriasis. In the present study we have used transcriptomic approaches to define the molecular make up of this response.

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Baldwin HM, Pallas K, King V, Jamieson T, McKimmie CS, Nibbs RJ, Carballido JM, Jaritz M, Rot A, Graham GJ