The peroxisome proliferator-activated receptor-gamma agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus

GSE45923

Homo sapiens

17 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Previous studies indicate that peroxisome proliferator-activated receptor-gamma (PPAR-g) agonists suppress autoimmune responses and renal inflammation in murine lupus. However, the mechanisms implicated in this process remain unclear. We tested the effect of the PPAR-g agonist pioglitazone in human lupus and control PBMCs with regards to gene regulation and various functional assays.

PubMed ID

23962407

Publication Title

The peroxisome-proliferator activated receptor-γ agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus.

Total Samples

Submitter’s Institution

University of Michigan

Authors

Zhao W, Berthier CC, Lewis EE, McCune WJ, Kretzler M, Kaplan MJ

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-45923

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