In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways

It has been recently shown that N-ras plays a preferential role in immune cell development and function; specifically: N-ras, but not H-ras or K-ras, could be activated at and signal from the Golgi membrane of immune cells following a low level TCR stimulus. The goal of our studies was to test the hypothesis that N-ras and H-ras played distinct roles in immune cells at the level of the transcriptome.

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Lynch SJ, Zavadil J, Pellicer A