Expression analysis of BL6 murine megakaryocyte progenitors from bone marrow and fetal Liver

About 10% of Down syndrome (DS) infants are born with a myeloproliferative disorder (DS-TMD) that spontaneously resolves within the first few months of life. About 20-30% of these infants subsequently develop acute megakaryoblastic leukemia (DS-AMKL). In order to understand differences that may exist between fetal and bone marrow megakaryocyte progenitor cell populations we flow sorted megakaryocyte progenitor cells and performed microarray expression analysis.

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Woo AJ, Wieland K, Huang H, Akie TE, Piers T, Kim J, Cantor AB