Genome-wide expression study of the early/innate responses of murine B and T cells to MCMV infection

Murine Cytomegalovirus (MCMV) infection leads to early activation of various immune cells, including B and T lymphocytes, before the actual initiation of antigen-specific adaptive immunity. This activation is partly driven by innate cytokines, including type I interferon (IFN), which are induced early after infection. The objective of this study was to address the role of type I IFN in shaping early/innate B and T cell responses to a primary acute viral infection.

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Manh TP, Alexandre Y, Baranek T, Crozat K, Dalod M