Transcriptional profile of AML xenografts treated with either PBS or a combination of decitabine and cytarabine

GSE44857

Homo sapiens

18 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

The Affymetrix Human Genome U133 Plus 2.0 Array was used to examine the Genome wide transcriptional changes which follow the treatment of AML xenografts with either PBS control or combination of decitabine (DAC) and cytarabine (Ara-C). Animals were treated with PBS, DAC alone, Ara-C alone, DAC and Ara-C combined (D+A), DAC followed by Ara-C (D/A) or Ara-C followed by DAC (A/D).

PubMed ID

24489920

Publication Title

Sequential treatment with cytarabine and decitabine has an increased anti-leukemia effect compared to cytarabine alone in xenograft models of childhood acute myeloid leukemia.

Total Samples

Submitter’s Institution

University of Birmingham

Authors

Leonard SM, Perry T, Woodman CB, Kearns P

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-44857

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