The effect of Sparstolonin B (SsnB) on gene expression in HUVECs

GSE44597

Homo sapiens

4 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Sparstolonin B is a novel bioactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. SsnB has previously demonstrated anti-angiogenic properties. In functional assays, SsnB inhibited endothelial cell tube formation (Matrigel method) and cell migration (Transwell method) in a dose-dependent manner.

PubMed ID

23940584

Publication Title

Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells.

Total Samples

Submitter’s Institution

University of South Carolina

Authors

Bateman HR, Liang Q, Fan D, Rodriguez V, Lessner SM

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-44597

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