-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/-catenin signaling

To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal carcinogenesis, we treated these cell lines with -catenin siRNA and identified -catenin target genes using DNA microarrays. The list of identified target genes was compared to previously published -catenin target genes found in the PubMed and the GEO databases.

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Herbst A, Jurinovic V, Krebs S, Thieme SE, Blum H, Göke B, Kolligs FT