GATA factors efficiently direct cardiac fate from ESCs

Gata5 efficiently promotes cardiomyocyte fate from murine ESCs.By removing serum from the culture conditions, GATA4 and GATA6 are each also able to efficiently promote cardiogenesis in ESC derivatives, with some distinctions. Thus, GATA factors can function in ESC derivatives upstream of other cardiac transcription factors to direct specification of progenitors with cardiac potential.

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Turbendian HK, Gordillo M, Tsai SY, Lu J, Kang G, Liu TC, Tang A, Liu S, Fishman GI, Evans T