Activation of beta-catenin in hepatocellular carcinoma (mouse Ctnnb1 knockout)

CTNNB1 is the most frequently mutated gene in hepatocellular carcinoma (HCC). However, its clinical relevance remains controversial. We determined an evolutionarily conserved -catenin signature by comparative analysis of gene expression data from human HCC (GSE43619) and a mouse model.

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Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD