Activation of beta-catenin in hepatocellular carcinoma (HCC patients)

CTNNB1 is the most frequently mutated gene in hepatocellular carcinoma (HCC). However, its clinical relevance remains controversial. We determined an evolutionarily conserved -catenin signature by comparative analysis of gene expression data from human HCC and a mouse model (GSE43628). We generated gene expression data from the tumors of 88 HCC patients who underwent surgical resection as the primary treatment. We used these gene expression data to develop a new prognostification model for prognosis of HCC after surgery.

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Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD