Expression data from MLL-AF6 positive leukemia cells

GSE43067

Mus musculus

3 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation system.

PubMed ID

23361907

Publication Title

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.

Total Samples

Submitter’s Institution

Dana-Farber Cancer Institute

Authors

Deshpande AJ, Chen L, Fazio M, Sinha AU, Bernt KM, Banka D, Dias S, Chang J, Olhava EJ, Daigle SR, Richon VM, Pollock RM, Armstrong SA

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-43067

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