Expression data from H295R cells where NRSF/REST or SF-1 were knocked down

SF-1 is a nuclear receptor transcription factor playing a key role in adrenogonadal development and in adrenocortical tumorigenesis when overexpressed. NRSF/REST is a transcriptional repressor that represses expression of neuronal genes in non-neural tissues. Some data suggest that SF-1 and NRSF/REST can functionally interact in adrenocortical cancer cells.

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Doghman M, Figueiredo BC, Volante M, Papotti M, Lalli E