Expression data from C. elegans in the presence or absence of copper sulfate

MAP kinases are integral to the mechanisms by which cells respond to a wide variety of environmental stresses. In Caenorhabditis elegans, the KGB-1 JNK signaling pathway regulates the response to heavy metal stress. The deletion mutants of this cascade show hypersensitivity to heavy metals like copper or cadmium. However, factors that function downstream of KGB-1 pathway are not well characterized.

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Hattori A, Mizuno T, Akamatsu M, Hisamoto N, Matsumoto K