Functional genomics in perinatal asphyxia and fetal asphyctic preconditioning in the brain

Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. Genomic reprogramming is thought to be, at least in part, responsible for the protective effect of preconditioning. Therefore, we investigated whole genome differential expression in the preconditioned rat brain.

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Cox-Limpens KE, Vles JS, LA van den Hove D, Zimmermann LJ, Gavilanes AW