Budding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [expression]

Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following its establishment in S-phase and its role in chromosome condensation.

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Lopez-Serra L, Lengronne A, Borges V, Kelly G, Uhlmann F