Expression profiles of wildtype and Shox2 knockout embryonic limbs

The development of vertebrate extremities is a complex process which requires a highly coordinated network of different transcriptional activities. The homeodomain transcription factor Shox2 is a key player in limb formation controlling neural, muscular and skeletal development. Here, we compared gene expression profiles of wildtype and Shox2 knockout limbs using microarray experiments to identify Shox2 target genes.

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Glaser A, Arora R, Hoffmann S, Li L, Gretz N, Papaioannou VE, Rappold GA