Expression data from HeLa cells treated with Casiopeina Cas-II-gly

Copper-based chemotherapeutic compounds Casiopeinas, have been presented as able to promote selective programmed cell death in cancer cells, thus being proper candidates for targeted cancer therapy. DNA fragmentation and apoptosis -in a process mediated by reactive oxygen species- for a number of tumor cells, have been argued to be the main mechanisms. However, a detailed functional mechanism (a model) is still to be defined and interrogated for a wide variety of cellular conditions; before establishing settings and parameters needed for their wide clinical application.

6

Valencia-Cruz AI, Uribe-Figueroa LI, Galindo-Murillo R, Baca-López K, Gutiérrez AG, Vázquez-Aguirre A, Ruiz-Azuara L, Hernández-Lemus E, Mejía C