Pancreatic gene expression associated with cerulein induced chronic pancreatitis in mice

GSE41418

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

A frequently used experimental model of chronic pancreatitis (PC) recapitulating human disease is repeated injection of cerulein to mice. We found that two common substrains of C57BL/6 , C56BL/6J (Jackson) and C57BL/6NHsd (Harlan), exhibit different degree of CP with C57BL/6J beeing more susceptible to repetitive cerulein induced CP. The goal of this study was to identify genes associated with CP and also to identify genes differentially regulated between two substrains as candidates for the CP progression.

PubMed ID

23845568

Publication Title

Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.

Total Samples

Submitter’s Institution

Saint Louis University

Authors

Ulmasov B, Oshima K, Rodriguez MG, Cox RD, Neuschwander-Tetri BA

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-41418

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