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Accession IconGSE41366

Alterations in gene expression in Caenorhabditis elegans associated with organophosphate pesticide intoxication and recovery

Organism Icon Caenorhabditis elegans
Sample Icon 146 Downloadable Samples
Technology Badge Icon Affymetrix C. elegans Genome Array (celegans)

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Description
The principal toxicity of acute organophosphate (OP) pesticides poisoning is the disruption of neurotransmission through inhibition of acetylcholinesterase (AChE). However, other mechanisms leading to persistent effects and neurodegeneration remain controversial and difficult to detect. Because Caenorhabditis elegans is relatively resistant to OP lethalityparticularly through the inhibition of AChEstudies in this nematode provide an opportunity to observe alterations in global gene expression following OP exposure that cannot be readily observed in less resistant organisms.
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