Expression data from E18.5 mouse dorsal telencephalon

GSE40675

Mus musculus

4 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

Radial progenitors deficient in both Mek1 and Mek2 fail to transition to the gliogenic mode in late embryogenesis, and astrocyte and oligodendroglial precursors fail to appear. In exploring mechanisms, we found the Ets transcription family member Etv5/Erm is strongly regulated by MEK. Our microarray assay showed that Erm is specifically downregulated in Mek mutant brain.

PubMed ID

22998872

Publication Title

MEK Is a Key Regulator of Gliogenesis in the Developing Brain.

Total Samples

Submitter’s Institution

University of North Carolina

Authors

Li X, Newbern JM, Wu Y, Morgan-Smith M, Zhong J, Charron J, Snider WD

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-40675

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