Expression data from AML1-ETO (AE)-expressing murine bone marrow (BM) cells treated with retinoids

AE-expressing murine BM cells treated with all-trans retinoic acid (ATRA) in semi-solid methycellulose-based cultures show an increase in self-renewal capacity whilst treatment with a specific RARa agonist NRX195183 reduces their clonogenicity. Gene expression analysis was performed to further investigate the molecular mechanisms underlying these observations. Upregulated gene sets were identified in the ATRA-treated AE BM cells.

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Chee LC, Hendy J, Purton LE, McArthur GA