Young and old HSCs from WT and Lnk-/- mice

GSE39553

Mus musculus

14 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

The adaptor protein Lnk is an important negative regulator of HSC homeostasis and self-renewal. This study aims to investigate the role of Lnk in HSC aging. Here we performed expression profiling of bone marrow CD150+CD48-LSK LT-HSCs from young and old WT and Lnk-/- mice. Results identify select Lnk-mediated pathways with potential involvement in HSC self-renewal and aging.

PubMed ID

22812478

Publication Title

Lnk deficiency partially mitigates hematopoietic stem cell aging.

Total Samples

Submitter’s Institution

Children's Hospital of Philadelphia, and University of Pennsylvania School of Medicine

Authors

Bersenev A, Rozenova K, Balcerek J, Jiang J, Wu C, Tong W

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-39553

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