Expression data from Saccharomyces cerevisiae WT, WT(hsf1), hac1 and hac1(hsf1)

In the yeast Saccharomyces cerevisiae, accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR) mediated by Hac1p, whereas the heat shock response (HSR) mediated by Hsf1p mainly regulates cytosolic processes and protects the cell from different stresses. In this study, we find that a constitutive activation of the HSR by over-expression of a mutant HSF1 gene could relieve ER stress in both wild type and hac1 UPR-deficient cells.

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Hou J, Tang H, Liu Z, Österlund T, Nielsen J, Petranovic D