Complement Factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.

Purpose: The complement system is closely linked to the pathogenesis of age-related macular degeneration (AMD). Several complement genes are expressed in retinal pigment epithelium (RPE), and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers increased risk of developing AMD. Because the mechanisms by which changes in the function of CFH influence development of AMD are unclear, we examined ocular complement expression as a consequence of age in control and CFH null mutant mice.

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Faber C, Williams J, Juel HB, Greenwood J, Nissen MH, Moss SE