Gene expression analysis in skeletal muscle and heart of 11 days-old TK2 knockout mice
12 Downloadable Samples
Affymetrix Mouse Gene 1.1 ST Array (mogene11st)
Submitter Supplied Information
TK2 deficiency causes severe mtDNA depeltion in several tissues, including skeletal muscle and heart. TK2 knockout mice grow slower and their skeletal muscles appeared significantly underdeveloped, whereas heart was close to normal size.