ATFS-1 mediates a protective transcription program during mitochondrial stress

ATFS-1 has been shown to regulate transcription of mitochondrial chaperone genes such as mtHsp70/hsp-6 and hsp-60 in response to mitocondrial stress. To identify the entire ATFS-1-mediated response, we compared the transcript profiles from wild-type and atfs-1(tm4525) worms raised in the absence and presence of mitochondrial stress.

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Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM