Gene activation by Rag-mediated DNA double-strand breaks in G1-phase murine pre-B cells

The objective is to identify genes that are differentially expressed following the introduction of DNA double-strand breaks (DSBs) by the Rag proteins in murine pre-B cells. Cells lacking Artemis are used since the Rag-induced DSBs will not be repaired, and thus, will provide a continuous stimulus to the cell.

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Innes CL, Hesse JE, Palii SS, Helmink BA, Holub AJ, Sleckman BP, Paules RS