Molecular Phenotyping of Immune Cells from Young NOD Mice

GSE37450

Mus musculus

60 Downloadable Samples

Affymetrix Mouse Expression 430A Array (moe430a), Affymetrix Mouse Expression 430B Array (moe430b)

Submitter Supplied Information

Description

Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse a model for human type 1 diabetes (T1DM). The molecular events leading to insulitis are poorly understood. Since TIDM is caused by numerous genes, we hypothesized that multiple molecular pathways are altered and interact to initiate this disease.

PubMed ID

23071669

Publication Title

Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes.

Total Samples

Submitter’s Institution

University of Tennessee Health Science Center

Authors

Wu J, Kakoola DN, Lenchik NI, Desiderio DM, Marshall DR, Gerling IC

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-37450

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