Identification of endoderm-specific genes in mouse embryos

The foregut definitive endoderm is the precursor of many tissues including the liver, pancreas, thyroid, lungs, trachea and oesophagus. However, networks and pathways involved in the early development of the definitive endoderm of mammals are not well studied. To identify genes with potential roles in the early development of the foregut definitive endoderm in mouse embryos, we performed microarray analysis to compare the gene expression profile of foregut endoderm and non-endodermal tissues from early somite-stage mouse embryos.

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Loebel DA, Studdert JB, Power M, Radziewic T, Jones V, Coultas L, Jackson Y, Rao RS, Steiner K, Fossat N, Robb L, Tam PP